HER2 and Breast Cancer

HER2-positive breast cancer (HER2+) is a subtype of breast cancer that makes too much of a protein called HER2. HER2 normally helps a healthy breast cell grow and divide. But in about 25 percent of breast cancers, the HER2 gene doesn’t work properly and makes too many copies of itself. As a result, HER2+ breast cancers tend to grow faster and are more likely to spread than other types of breast cancer.her2-3

Fortunately, therapies that specifically target HER2, such as tratuzumab (Herceptin), are very effective and have had a significant impact on breast cancer survival for women with HER2+ breast cancer.

In spite of these advances, some HER2+ breast cancers do not respond to these therapies or become resistant to therapy. Komen is dedicated to finding new strategies for treating HER2+ breast cancer and identifying which women are most likely to respond to them.



To learn more about molecular sub types of breast cancer, click here.